The I/O registry is a resource developed across six academic and community medical centers in DC, MD, and NJ. We have identified about 3500 cancer patients including from diverse ethnic groups and races with complete medical records, comorbidities and outcomes.

Our IO registry is one of the largest and most diverse real world IO outcomes registries used to answer many real world IO outcomes questions. We believe that the well-curated IO registry that integrates demographics, comorbidities, diagnosis, treatment therapies, pathology, and molecular profiling is a great approach to help us answer various questions which cannot be addressed through individual hospital‐based datasets. Given our large and diverse patient population, we can leverage the registry and successfully develop irAEs biomarker model. Our work including findings, methods and approaches are presented at National and International conferences.